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There are some eye conditions where your doctor might recommend an eye injection as a treatment option.

Injections into the eye, specifically into the vitreous or gel-filled cavity of the eye, are called intravitreal injections.

Anti-vascular endothelial growth factors (anti-VEGF) are probably the most commonly injected agents. They are used to treat wet age-related macular degeneration (ARMD), diabetic retinopathy, and retinal vein occlusion.

In these conditions, there are abnormal leaky blood vessels that cause fluid and blood to accumulate in and under the retina. This accumulation of fluid results in loss of central vision. The role of anti-VEGF agents is to shrink these abnormal vessels and restore the normal architecture of the retina.

Three anti-VEGF agents that are widely administered are Lucentis, Avastin, and Eylea.

Lucentis (Ranibizumab) is FDA approved for treatment of wet ARMD, diabetic retinopathy, and vein occlusion. It is specially designed for injection into the eye and is a smaller molecule than Avastin so it may have better penetration into the retina.

Avastin (Bevacizumab) was originally approved by FDA for treating colorectal cancer. It is used “off-label” for the same treatment indications as Lucentis. Off-label usage of medication is legal, but pharmaceutical companies can't promote a medication for off-label use. The amount of Avastin needed for eye injections is a fraction of the amount used to treat colorectal cancer, therefore, the cost of ophthalmic Avastin is only a fraction of the cost of Lucentis. This means that Avastin needs to be prepared sterilely into smaller doses by an outside pharmacy prior to injection into the eye.  

Eylea (Aflibercept) is the third anti-VEGF agent. It was designed to have more binding sites than Avastin and Lucentis so it may last longer in the eye than the former two.  Eylea is FDA approved for treatment of wet ARMD, diabetic disease, and vein occlusion, and therefore, the cost of Eylea is similar to the cost of Lucentis.

There are also newer agents on the market.  Your doctor will determine which might work best for you.

There is a thought that after prolonged injections, some patients may develop resistance to one particular agent but still respond to the a different agent. Therefore, your surgeon will individualize your treatment.

There have been studies undertaken over the past several years to try and understand if there are any of our day-to-day activities that either help or hurt the management of glaucoma.

Most of the studies demonstrated very little impact on the course of glaucoma. Here are some of the things researches have looked at.

Aerobic exercise: This means doing something at least four times per week for more than 20 minutes at a time that raises your pulse rate to a level that makes your heart work harder. Going from a sedentary lifestyle to active one with aerobic exercise resulted in a very slight decrease in baseline eye pressure.

Yoga: A study conducted at the Mount Sinai Health System (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144505) showed a significant increase in eye pressure with any head-down positioning. People with glaucoma would be wise to avoid any exercise that involves a position where your head is lower than your heart.

Weight lifting: Holding your breath while exerting yourself (called the Valsalva maneuver), is also a time when your eye pressure can go sky high. So if you lift weights for exercise, which is generally a good idea to maintain bone density, make it low weights with more repetitions of lifting, rather than heavy weights that make you grunt.

Wind instruments: A similar breath-holding problem applies to those playing the larger wind musical instruments like the French horn. One study suggested that there was a greater chance of glaucoma in symphonic wind players. If you play a brass instrument, it makes sense to have frequent checks of pressure, optic nerve head, and visual field.

Marijuana: Smoking marijuana can lower eye pressure. However, due to its short duration of action (3-4 hours), side effects, and lack of evidence that it alters the course of glaucoma, it is not recommended for glaucoma treatment.

Wearing tight neckties: This creates a very short-duration increase in eye pressure but doesn’t seem to have any long-term effects.